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The secretariat is in charge of the technical aspects of implementing projects. The secretariat is headed by an Executive Director  who is complemented by 4 other technical staff with different roles including finance officer, a Programme officer, an administrative assistant/Interpreter and a Field assistant.

Sign Health Uganda is governed by a Board of Trustees (BOT) of 9 members, headed by a Chairperson. The key feature of Sign Health Uganda Board is that members have a balance of skills, experience and relevant expertise in various fields. The role of the Board of Trustees is to provide effective policy formulation and guidance, strategic decision-making, as well as supervision of the plan implementation.